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David J. Margolis, MD, PhD

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David J. Margolis, MD, PhD

Professor of Dermatology and Epidemiology

Dr. Margolis's research work is focused on dermatoepidemiology and, more specifically, the epidemiology and treatment of chronic wounds. It is important to realize that more than seven million Americans suffer from these wounds and that  the U.S. spends more than $10 billion per year caring for individuals with these medical problems. He has been and is currently is the principal investigator of several grants from the Naitonal Institutes of Health, the Food and Drug Admistration, and the Agency for Healthcare Research and Quality, as well as from industry and from foundations. These studies focus on chronic wounds (such as diabetic foot ulcers and venous leg ulcers). Recent work has also focused on atopic dermatitis both the natural history of this disease as well as the genetics of atopic dermatitis.

His contributions are important to our current understanding and practice regarding the design, choice of surrogate endpoints, and statistical analysis plan of studies addressing wound repair. The clinical assessments he innovated are now routinely incorporated into clinical trials designed to explore new treatments of venous legs and diabetic foot ulcers. Additional evidence of their importance is their incorporation into clinical treatment and evaluation guidelines used by insurers. He also has studies on the genetics of atopic dermatology, severe cutaneous drug eruptions, antibiotic use in acne, and the safety of therapy for dermatologic illnesses. His work focuses on epidemiologic study designs, comparative effectiveness designs and clinical trials. He is the founding director of the Center for DermatoEpidemilogy and Translation of the Perelman School of Medicine. He has published more than 300 scientific papers and frequently lectures at national and international meetings.

Content Area Specialties

Aging, atopic dermatitis, chronic wounds, diabetic foot ulcer and amputation, venous leg ulcer, cancer epidemiology, infectious diseases, patient-oriented research, pharmacoepidemiology, dermatology
 

Methodology Specialties

Categorical data, clinical trials, diagnostic testing, meta-analysis, administrative data, outcomes,

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