“Instead of shooting arrows in the dark to find a drug that would be beneficial, we can now make an informed choice about the beneficial and harmful effects of pharmacological inhibition of a wide range of pathways,” comments Danish Saleheen, MBBS, PhD, one of the lead authors of a major study in Nature this week. An international research collaborative team studied more than 1,800 individuals who carried loss-of-function mutations in both copies of their genes, so-called “human knockouts."
To understand health and disease today, we need new thinking and novel science —the kind we create when multiple disciplines work together from the ground up. That is why this department has put forward a bold vision in population-health science: a single academic home for biostatistics, epidemiology and informatics. MORE