Robert Gross, MD, MSCE



Robert Gross, MD, MSCE

Associate Professor of Medicine and Epidemiology

Dr. Gross is board certified in infectious diseases and epidemiology and is associate professor of medicine and epidemiology in the Division of Infectious Diseases, with a secondary appointment in the Division of Epidemiology in the Department of Biostatistics and Epidemiology. Dr. Gross is an infectious diseases pharmacoepidemiologist with a particular interest in treatment outcomes of chronic viral infections, including HIV and viral hepatitis (i.e., HCV, HBV). His projects have focused on several aspects of the care continuum, including assessment of risk factors for treatment failure and testing various interventions to improve outcomes in the developed and developing worlds. He designed and tested the National Institute of Mental Health (NIMH) R01-funded adherence intervention based on problem solving theory (MAPS-Managed Problem Solving).* He has been principal investigator or co-investigator on several other interventions, including AIDS Clinical Trials Groups RCTs.

His methods work focuses on the use of pharmacy-refill measures of antiretroviral adherence, and he has refined this approach over the last several years. Dr. Gross also has a research program ongoing in Botswana, where he has held an NIMH R01-funded cohort study and case-control study enrolling over 2000 participants to determine the impact of pharmacogenetic differences on HIV treatment outcomes. He also holds a Fogarty grant (D43) for training Botswana in HIV clinical epidemiology.

Administratively, Dr. Gross has been actively involved in the PENN Center for AIDS Research (CFAR) since its inception and currently serves as CFAR co-director. He is also active in the International Society of Pharmacoepidemiology (ISPE), where he founded the Adherence Scientific Interest Group. He is a fellow of both ISPE and the Infectious Diseases Society of America (IDSA) and provides clinical infectious diseases care at the Crescenz VA Medical Center.

*Find the Treatment Manual for Managed Problem Solving  here.


Content Area Specialties


Adherence, infectious diseases, patient-oriented research, psychosocial

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