DBEI | CCEB  |  Intranet

Quantifying and Comparing Bacterial Growth: Method Charts Path Toward New Treatments

Quantifying and Comparing Bacterial Growth: Method Charts Path Toward New Treatments

November 2018

The human microbiome plays an important role in human health and disease, and shotgun metagenomics provide a powerful method for studying the microbial communities it contains. However the resulting data are very big. We need new statistical and computational tools to make sense of the data and to identify important biological features.

Current methods provide only static features of microbial communities. The authors developed a new statistical method to study the growth dynamics of bacteria, which can effectively identify the bacteria that show differential growth rates between diseased and normal individuals, such as patients with inflammatory bowel disease. The results can potentially be used to develop disease treatments by inhibiting or promoting bacterial growth.

Authors: 

Yan Gao, Hongzhe Li

Share this Content

About Us

To understand health and disease today, we need new thinking and novel science —the kind  we create when multiple disciplines work together from the ground up. That is why this department has put forward a bold vision in population-health science: a single academic home for biostatistics, epidemiology and informatics. MORE

© 2019 Trustees of the University of Pennsylvania. All rights reserved. | Disclaimer

Follow Us