Dr. Nesoff is a social epidemiologist focused on the intersection of substance use, the neighborhood environment, injury prevention, and health disparities. Her current research uses spatial analysis methods to investigate the relationship between modifiable neighborhood features and opioid overdose risk. Her research has been funded by the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism. Her current projects, funded by NIH/NIDA, use mixed quantitative and qualitative methods to investigate how the neighborhood built environment impacts mental health and opioid overdose risk. The first phase of this research combines GIS, spatial analysis, and systematic social observation methods to explore changing patterns in drug use, including types of drugs used, locations where drugs are used, and associated overdose risk. Recent publications from this work include investigations into how place impacts fatal overdose for people experiencing homelessness and improvements to community naloxone access in New York City.  She has received several awards for her research, including an early career investigator award from the College on Problems of Drug Dependence.